While performing at her Las Vegas residency, “Enigma,” Lady Gaga gave some shout outs to the stars that were in the audience including Diane Von Furstenberg, Chelsea Clinton, Kathy Bates and BFF to Oprah Winfrey, GAYLE!  She asked Gayle for a very important favour, to give Oprah a message.  “Pass this message on to the Big O. Just promise me you’ll ask her to consider at some point running for president—Oprah Winfrey, Oval Office, double-‘O.’ It makes sense to me.”  Watch the video below to see Gaga talking to Gayle from the stage.